Researchers find melatonin worsens asthma

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A study by Kentaro Mizuta of Tohoku University Graduate School of Dentistry found that the sleep hormone, melatonin, worsens asthma. The research was published in the American Journal of Physiology Lung Cellular and Molecular Physiology.

Asthma patients suffer from bronchoconstriction, where smooth muscles in the bronchus – the pathway that carries air to and from your lungs – contract. To relieve this, many take a bronchodilator, a medicine that widens the bronchi. However, melatonin, which is often prescribed for insomnia, promoted a state of bronchoconstriction and weakened the relaxing effect of a bronchodilator by activating the melatonin MT2 receptor.

To elucidate this, the research group identified the expression of the melatonin MT2 receptor in the smooth muscle of the human airways. They observed that activation of the melatonin MT2 receptor with higher doses of melatonin or melatonin receptor agonist ramelteon significantly potentiated bronchoconstriction. In addition, melatonin attenuated the relaxing effects of the widely used bronchodilator beta-adrenergic receptor agonist. “Although the serum melatonin concentration did not significantly induce airway constriction, higher doses of melatonin, which is clinically used to treat insomnia, jet lag or cancer, made symptoms worse. asthma and impaired the therapeutic effect of bronchodilators, ”Mizuta said.

The first author of the article, Haruka Sasaki, added: “Pharmacological therapy that blocks the melatonin MT2 receptor could inhibit the harmful effects of melatonin on the airways.”

(This story was not edited by Devdiscourse staff and is auto-generated from a syndicated feed.)


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